BPR072
Research Article
SYNTHETIC STUDIES ON NOVEL NITROQUINAZOLINONE ANALOGS WITH ANTIMICROBIAL POTENTIAL
Rajiv Dahiya1*, Rita Mourya2
1Department of Pharmaceutical Chemistry, Globus College of Pharmacy, Bhojpur Road,
Bhopal, Madhya Pradesh, India
2Research Scholar, Institute of Pharmaceutical Science and Research Center, Bhagwant University,
Sikar Road, Ajmer, Rajasthan, India
Bull. Pharm. Res. 2013; 3(2):51-7.
Abstract
A novel series of 4-[2-(3-bromophenyl)-7-nitro-4-oxo-3,4-dihydro-3-quinazolinyl]benzoyl amino acids and di/tripeptides was synthesized using diisopropylcarbodiimide (DIPC) as the coupling agent and N-methylmorpholine (NMM) as the base. Structures of all the newly synthesized peptide analogs were elucidated using IR, 1H/13C NMR, MS spectral data and evaluated for antimicrobial potential against pathogenic microbes. Most of the compounds exhibited potent antifungal activity against pathogenic Candida albicans and dermatophytes, in comparison to reference compound. Good bioactivity was also seen against gram-negative bacteria for synthesized compounds.
Key words: Quinazolinones, 4-Nitroanthranilic acid, Peptide analogs, Coupling, Antifungal activity.
*Correspondence: Dr. Rajiv Dahiya (drrajivdahiya@gmail.com)
(References: 32, Total Pages:07)
(Received: March 16, 2013, Accepted: May 21, 2013)